Pediatric Toxidrome Simulation Curriculum: Lidocaine-Induced Methemoglobinemia
نویسندگان
چکیده
منابع مشابه
Methemoglobinemia induced by lidocaine-prilocaine cream.
With growing awareness of the importance of pain control in all procedures, the use of lidocaine-prilocaine cream (EMLA) for all ages is increasing. Lidocaine-prilocaine cream has been implicated as a cause of methemoglobinemia. Diagnostic clues may be oxygen-resistant cyanosis and an oxygen "saturation gap" between arterial blood saturation and pulse oximetry. Treatment with intravenous methyl...
متن کاملLidocaine-induced methemoglobinemia: a clinical reminder.
Methemoglobinemia is a rare condition in which the iron in hemoglobin is stabilized in the ferric (Fe(3+)) form, making it unable to bind oxygen and leading to tissue hypoxia and possibly death. The condition may be hereditary or acquired, the latter resulting from ingestion or application of common oxidizing agents such as lidocaine. As management of methemoglobinemia depends on prompt recogni...
متن کاملBenzocaine and lidocaine induced methemoglobinemia after bronchoscopy: a case report
INTRODUCTION Methemoglobinemia is a rare cause of hypoxemia, characterized by abnormal levels of oxidized hemoglobin that cannot bind to and transport oxygen. CASE PRESENTATION A 62-year-old male underwent bronchoscopy where lidocaine oral solution and Hurricaine spray (20% benzocaine) were used. He developed central cyanosis and his oxygen saturation was 85% via pulse oximetry. An arterial b...
متن کاملA Case of Toxic Methemoglobinemia following Lidocaine Application for Circumcision
Toxic methemoglobinemia is a potentially life-threatening condition. It develops generally as a complication of the use of local anesthetics. Prompt recognition and quick institution of therapy is of utmost importance. In this paper, a case of methemoglobinemia that occurred after lidocaine application for circumcision is presented in order to increase awareness among clinicians about this cond...
متن کاملPrilocaine- and lidocaine-induced methemoglobinemia is caused by human carboxylesterase-, CYP2E1-, and CYP3A4-mediated metabolic activation.
Prilocaine and lidocaine are classified as amide-type local anesthetics for which serious adverse effects include methemoglobinemia. Although the hydrolyzed metabolites of prilocaine (o-toluidine) and lidocaine (2,6-xylidine) have been suspected to induce methemoglobinemia, the metabolic enzymes that are involved remain uncharacterized. In the present study, we aimed to identify the human enzym...
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ژورنال
عنوان ژورنال: MedEdPORTAL
سال: 2021
ISSN: 2374-8265
DOI: 10.15766/mep_2374-8265.11089